EndosQ's research

Results published: RCT examining the effect of hookworm infection on wheat challenge in patients with coeliac disease

Our new PLOS One publication regarding the results of a double-blinded, placebo-controlled study helps advance treatment of patients with coeliac disease. Our pilot study examined experimental infection with the hookworm Necator americanus with otherwise healthy people with coeliac disease in order to test the potential of the helminth to suppress the immunopathology induced by gluten. Results showed that the intervention was safe and and the results have helped move the health care community closer to testing its effect on a range of human autoimmune response measures. The full study was published in 2011 in PLOS One. Since this time it has been viewed, as of August 2013, by 6,200 people and cited 34 times – demonstrating considerable reach and impact of our study.

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